Bioavailability and Bioequivalence

Bioavailability is defined as rate and extends of absorption of unchanged drug from its dosage form and until it become available at the site of action. Bioavailability of a drug depends upon pharmaceutical factors, patient related factors and route of administration. Bioequivalence refers to the drug substance in two or more identical dosage forms, reaches the systemic circulation at the same relative rate and to the same relative extent i.e. their plasma concentration- time profiles will be identical without significant statistical differences. When statistically significant differences are observed in the bioavailability of two or more drug products, bioequivalence is indicated.

  • Relative Bioavailability
  • Bioequivalence Assessment
  • Hepatic First-Pass Effect
  • Factors Influencing Bioavailability
  • Route of Administration
  • In vitro Bioequivalence
  • Therapeutic Index
  • Bioequivalence of Endogenous Substances
  • Generic Drugs

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