Oncology Clinical Research

Phase I dose-finding trials, phase II studies to establish efficacy in a single tumour type, phase III trials contrasting current standards of care with potential improvements in care, and phase IV studies extending safety and activity data in a post-marketing scenario are now part of the science of clinical trials in oncology. As a result, we can anticipate greater cure rates for some metastatic tumours as well as locally contained cancers. For patients who received treatment outside of clinical trials and trial participants who had advanced stages of malignant diseases, researchers have significantly increased median overall survival statistics. Patients participating in clinical trials for advanced colorectal cancer are an illustration of this extension of median overall survival in the presence of advanced, incurable disease.

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