Asad Khan Tanoli
University of Karachi, Pakistan
Title: Metal complexes from bishydrazones ligands; design, characterization and antileishmaniasis activities
Biography
Biography: Asad Khan Tanoli
Abstract
Leishmaniasis, a complex vector-borne disease instigated by more than 20 species of the protozoan genus Leishmania and hosting more than 300 million people. The limited therapeutic options and the increasing drug resistance against the conventional anti-leishmanial drugs, urge the need for development of new leishmanicidal agents. In the recent era, antiparasitic properties of metal complexes have been widely studied. A variety of hydrazones derivatives along with their metal complexes have been reported as antiparasitic agents. In this work, coordination complexes from first series of transition metals were synthesized using hydrazone derivatives as bidentate ligands. All the synthesized compounds have been characterized by using different techniques i.e. elemental analysis (CHN), SEM, EI-Mass, 1-H NMR, 13C NMR, UV–Visible spectroscopy, IR spectroscopy, ESR and magnetic susceptibility measurements. Based on the analytical and spectral data octahedral geometry have been assigned to all the complexes. Synthesized metal complexes were evaluated for their in vitro antiparasitic potential. Metal complexes were found to be good leishmanicidal agents.