^{2nd Middle East Pharmacy and Pharmaceutical Conference}

There have been various efforts in designing different drug delivery systems (DDSs) for periodontal diseases based on the functionalized nanomedicines. The aim of this study is to review the recent treatment of periodontal diseases with nanomaterials. Moreover, this study also focuses on basic principles of utilizing the nanomaterials to create better DDSs for treatment of periodontal diseases. This type DDSs have numerous advantages include improved efficacy, reduced toxicity and improved patients compliance and convenience. Novel DDSs are being introduced for the treatment of periodontal diseases. Examples of these DDSs can be listed as follows: films, nanogels, nano-micro particles, liposomes, nanofibers, quantum dots, nanopores, nanotubes, nanofillers, nanocomposites, scaffold etc. Many drugs used in periodontal diseases have been encapsulated into these systems. Examples of these encapsulated drugs can be listed as follows: tetracycline, doxycycline, minocycline, metronidazole etc. The treatment of periodontal disease with new DDSs mentioned at above section, represent a step forward toward successful long-term healing by increasing the treatment efficacy, specificity, tolerability and therapeutic index of encapsulating drugs. Main treatment strategies in periodontal disease with nanomaterials are removal of microbial biofilm, delivery of novel active compounds for host inflammatory response modulation and supporting regeneration of periodontal tissue. By the improvement in the periodontal DDSs, it can be emphasized that the nanotechnology which is antibiotic free, mucoadhesive, biodegradable has a huge opportunity for designing a novel, low dose, and effective treatment. It will make possible for Nano dentistry to maintain the comprehensive oral health by employing nanomaterials, biotechnology which includes the tissue engineering and dental nanorobotics. Even though this technology is at a primary stage, it has already made a profound clinical and commercial impact in the field of dentistry.