Heyam Saad Ali,
University of Khartoum, Sudan
Title: Targeted liposomes and theranostic applications in cancer treatment
Biography
Biography: Heyam Saad Ali,
Abstract
Traditional chemotherapy is not recommended in the clinical settings due the severe complications patients exercising during use. Some of these complications include: severe systemic problems, [MDR] and toxicity. The reasons of such off-targeted side effects are due to the poor specificity and selectivity of drug deliver systems to target the biological molecule in the site of cancerous tissue. Therefore, advancement in the targeted delivery systems using nanotechnology techniques and Nano carriers are the area of interest and attention of many researchers, scientists and academia’s. Currently, significant developments, approaches and strategies are utilized to target the cancerous tissue. From these strategies of targeting the drug delivery is using Nano carriers such as liposomes, polymer nanoparticles, dendrimers etc. In addition to strengthen the conjugation to the selected extracellular and intracellular biological molecules such as receptors, carbohydrate determinant antigen, antibodies etc. Further more, utilizing the biological microenvironment surrounding the cancerous tumor, such as in passive targeting, and PEGylated liposomes to overcome the biological barriers through its journey to the cancerous tissue or cells. Moreover, the Nano carrier can be functionalized with directed ligands [active targeting] and physical responsive stimuli using the relevant techniques for a particular application. This presentation will high lights various current and recent strategies to overcome the limitation of conventional chemotherapy. However, nanotechnology is still in infancy since a lot of toxicity of the used nanomaterials and ethical issues have not been resolved yet. cell receptors via surface-attached ligands that direct drug uptake into tumor cells or tumor-associated stromal cells, and so can increase the selectivity of drug delivery.